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Genetic Vaccines for Infectious Disease
Infectious diseases such tuberculosis and HIV/AIDS claim millions
of lives a year worldwide. Developing vaccines to combat these diseases
present scientific challenges.
Researchers at LCTRC are exploring new vaccination
strategies against these diseases for which conventional vaccines
have failed. One approach is based on the use of DNA vaccines to
introduce a single artificially copied pathogen gene in order to
produce an immunological response. The immune system will recognize
the antigen as foreign and remember it, as in a traditional vaccination.
Other methods include viral vectors that carry genes encoding vaccine
antigens and the use of specific proteins or molecules as immunological
targets.
Pamela Kozlowski, PhD
Alistair Ramsay, PhD
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