Yan Cui, PhD Pamela Kozlowski, PhD Alistair Ramsay, PhD Jakob Reiser, PhD Guoshun Wang, PhD Xianyang Zhang, PhD
Arrigo De Benedetti, PhD Wei-Ming Duan, PhD Ronald Klein, PhD Benjamin Li, MD J. Michael Mathis, PhD Cherie-Ann Nathan, MD Kate Ryman, PhD Francesco Turturro, MD B. Jill Williams, PhD Qian-Jin Zhang, PhD Li-Ru Zhao, PhD
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1615 Poydras Street - Suite 1000
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Tulane University Health Sciences Center Areas of Research: Adult Stem Cells Dr. Gregory studies the role of human mesenchymal stem cells (hMSCs) from bone marrow stroma in bone development and repair. His recent work has highlighted the importance of Wnt signaling in MSC-mediated bone repair in health and disease. MSCs from the bone marrow are progenitors of osteoblasts, the cells that build and maintain bone tissue. The process of osteoblast differentiation, and subsequent repair of bone is driven by canonical Wingless (Wnt) signaling within the MSC. It has been demonstrated that the presence of Wnt signaling inhibitors such as Dkk-1 can disrupt the repair of bone and its secretion by tumors into the bone can lead to irreparable damage to the tissue. Recent Publications Gunn, W.G., Conley, A., Prockop, D.J., Gregory, C.A. A crosstalk between myeloma cells and marrow stromal cells stimulated production of DKK1 and IL-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma. Stem Cells, (2005) Gregory, C.A., Ylostalo, J., Prockop, D.J. Adult bone marrow stem/progenitor cells (MSCs) are pre-conditioned by micro-environmental "niches" in culture: a two-stage hypothesis for regulation of MSC fate. Science STKE, (2005) 294:37 Gregory, C.A., Perry, A.S., Reyes, E., Conley, A., Gunn, W.G., Prockop, D.J. Dkk-1 derived synthetic peptides and lithium chloride for the control and recovery of adult stem cells from bone marrow. Journal of Biological Chemistry, (2004) 280:2309-2323 Gregory, C.A., Singh, H., Perry, A.S., Prockop, D.J. Dkk-1 is required for re-entry into the cell cycle of human adult stem cells from bone marrow stromal (hMSCs). Journal of Biological Chemistry, (2003) 278:28067-78 |
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Carl Gregory, PhD