right click image to download
Research Directory

1615 Poydras Street - Suite 1000
New Orleans, LA 70112
504.525.5744 voice
504.525.7787 fax

Radhika Pochampally, PhD

Tulane University Health Sciences Center

Areas of Research: Adult Stem Cells Biology

The general focus of Dr. Pochampally's research is to understand the survival properties of serum deprivation resistant mesenchymal stem cells (SD-MSCS) and their therapeutic potential in various disease models. SD-MSCs are the most primitive subpopulation
in the heterogeneous population of mesenchymal stem cells from bone marrow.
Current projects include studying the role of epigenetic regulation, micro-RNA regulation and post translational regulation in the survival of the SD-MSCs, and the engraftment and differentiation potential of MSCs and SD-MSCs in acute mouse myocardial infarction and in chick embryo models. Dr. Pochampally is also interested in characterizing the cancer stem cells of osteosarcoma.

Selected Publications

Iso, Y., Spees, J., Serrano, C., Pochampally, R.R., Song YH., Sobel, B., Delafontaine, P., and Prockop, D.J. Systemic administration of human marrow stromal cells improves cardiac function after myocardial infarction in immunodeficient mice without long-term cardiac engraftment.(2006) (In press BBRC)

Pochampally, R.R. A subset of human rapidly-self renewing marrow stromal cells (MSCs) preferentially engraft in mice. Blood. (2005)

Pochampally, R.R., Horwitz, E.M., DiGirolamo, D.M., Stokes, D.S., and Prockop, D.J. Correction of a mineralization defect by overexpression of a wild-type cDNA for COL1A1 in osteogenesis
imperfecta: a strategy for rescuing mutations that produce dominant-negative protein defects. Gene Therapy, (2005) July; 12(14): 1119-1125

Pochampally, R.R., Smith, J., and Prockop, D.J. Serum deprivation of human marrow stromal cells (hMSCs) selects for a sub-population of early progenitor cells with enhanced expression of
OCT-4 and other embryonic genes. Blood, (2004) 103(5): 1647- 57