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1615 Poydras Street - Suite 1000
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Louisiana State University Health Sciences – New Orleans Areas of Research: Viral Vector Development for Neurological Disease Our laboratory is working on the design of gene delivery systems, particularly recombinant viral vectors, to treat neurological disorders including lysosomal storage diseases. Krabbé disease, a central and peripheral nervous system disorder is cause by a genetic defect in the gene encoding the lysosomal enzyme galactosylceramidase (GALC). Like most chronic neurodegenerative disorders, effective treatment for Krabbé disease are impeded by the structural and functional complexity and relative inaccessibility of the central nervous system. Our goal is to develop improved lentivirus-based gene and protein transfer strategies for the central and peripheral nervous systems. Selected publications Zhang, XY., Kutner, R., La Russa, V., and Reiser, J. Transgene delivery into mesenchymal stem cells using lentiviral vectors. In: Stem Cells: Research Tools and Transplantation. Methods in Molecular Biology. (2007) V. LaRussa (Ed.). The Humana Press Inc. Song, Y., Zhang, Z., Yu, X., Yan, M., Zhang XY., Gu, S., Stuart, T., Liu, C., Zhang, Y., Reiser, J. and Chen, Y. Application of lentivirus-mediated RNAi in studying gene function in mammalian tooth development. Developmental Dynamics, (2006) 235:1347-1357 Cronin, J., Zhang, X-Y., and Reiser, J. Altering the tropism of lentiviral vectors through pseudotyping. Current Gene Therapy, (2005) 5:387-398 |
